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The present invention relates to methods, kits, and compositions for generating purified RNA samples and purified DNA samples.

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In other embodiments, the particles comprising two or more magnetic cores are covered by a zeolite or acid zeolite coating.In certain preferred embodiments, the binding matrix comprises binding particles (e.g.zeolites, acid zeolites, a solid acid catalyst, etc.).In additional embodiments, the binding matrix, whether in an acidic buffer or not in an acidic buffer, comprises binding particles, a composition coated with binding particles, or a solid support.In particular embodiments, the binding matrix is magnetic and the separating step is performed with magnetic separation type techniques.

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